Synthesis of labelled PNA oligomers by a post-synthetic modification approach.
نویسندگان
چکیده
The preparation of t-butoxycarbonyl (Boc)-protected O(4)-(o-nitrophenyl) thymine peptide nucleic acid (PNA) monomer is described. This PNA monomer was incorporated into PNA oligomer sequences. The post-synthetic modification of the oligomers to yield fluorescently-labelled PNA oligomers was studied before and after the removal of the protecting groups. In both cases, the desired fluorescently-labelled PNA oligomer was obtained in good yields.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 13 3 شماره
صفحات -
تاریخ انتشار 2003